Gene information
Official symbol MMP3
Official full name matrix metallopeptidase 3
Gene type protein-coding gene
Chromosome11q22.2
Previous symbolSTMY1; STMY
Gene familyM10 matrix metallopeptidases
Resources
Entrez Gene 4314
HGNC HGNC:7173
Ensembl ENSG00000149968
Vega OTTHUMG00000048254
UCSC uc001phj.2
GO terms: 45 records
GO Description Category LogP Number of genes Detail
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004222 metalloendopeptidase activity GO Molecular Functions -10.6700212 15 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008237 metallopeptidase activity GO Molecular Functions -10.3008607 18 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010310 regulation of hydrogen peroxide metabolic process GO Biological Processes -2.79007403 3 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031334 positive regulation of protein-containing complex assembly GO Biological Processes -8.84926570 16 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0034644 cellular response to UV GO Biological Processes -5.54644403 9 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043254 regulation of protein-containing complex assembly GO Biological Processes -7.63830100 21 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0070141 response to UV-A GO Biological Processes -7.87763977 6 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071478 cellular response to radiation GO Biological Processes -4.2266687 10 More
GO:0071482 cellular response to light stimulus GO Biological Processes -4.67282705 9 More
GO:0071492 cellular response to UV-A GO Biological Processes -8.67610245 6 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:1900407 regulation of cellular response to oxidative stress GO Biological Processes -21.4526227 33 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1902882 regulation of response to oxidative stress GO Biological Processes -20.0046302 33 More
GO:1903201 regulation of oxidative stress-induced cell death GO Biological Processes -18.4601079 28 More
GO:1904645 response to amyloid-beta GO Biological Processes -11.2505232 12 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
GO:2000378 negative regulation of reactive oxygen species metabolic process GO Biological Processes -8.33338139 14 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05215 Prostate cancer KEGG Pathway -7.21675759 11 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
berkeleyacetal a DTC 17970594 view
berkeleyacetal b DTC 17970594 view
berkeleyacetal c DTC 17970594 view
berkeleyamide b DTC 18330993 view
berkeleyamide c DTC 18330993 view
berkeleydione DTC 17970594 view
berkeleytrione DTC 17970594 view
chlorthalidone PharmGKB view
lisinopril PharmGKB view
marimastat inhibitorantagonist TdgClinicalTrialTEND 11752352 view
pravastatin PharmGKB 10190398 view
prinomastat vaccine TALC view
Related studies: 23 records
Molecular factor Omics type Application Objective MI type Reference
NM_002422.5:c.-376C>G genomics myocardial infarction[diagnosis] myocardial infarction Zhou X et al. Thromb Haemost. 2004
NM_002422.5:c.[-1612dup;-376C>G;1161G>A] genomics myocardial infarction[diagnosis] myocardial infarction Zhou X et al. Thromb Haemost. 2004
NG_012100.1:g.[4295A>G;7762G>C;13685G>C;14446T>C] genomics myocardial infarction[diagnosis] myocardial infarction Kaplan RC et al. Atherosclerosis. 2008
stromelysin-1 proteomics left ventricular ejection fraction[other] acute myocardial infarction Kelly D et al. Eur Heart J. 2008
stromelysin-1 proteomics left ventricular end-systolic volume[other] acute myocardial infarction Kelly D et al. Eur Heart J. 2008
stromelysin-1 proteomics left ventricular end-diastolic volume[other] acute myocardial infarction Kelly D et al. Eur Heart J. 2008
stromelysin-1 proteomics poor predictor death;heart failure[prognosis (bad)] acute myocardial infarction Kelly D et al. Eur Heart J. 2008
stromelysin-1 proteomics good predictor cardiovascular death[prognosis (bad)] acute myocardial infarction Berezin AE et al. Asian Cardiovasc Thorac Ann. 2013
stromelysin-1 proteomics myocardial infarction[diagnosis] myocardial infarction Cavusoglu E et al. Am J Cardiol. 2016
stromelysin-1 proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Pecherina T et al. Diagnostics (Basel). 2020
NM_002422.5:c.-1612dup genomics acute myocardial infarction[diagnosis] acute myocardial infarction Terashima M et al. Circulation. 1999
NM_002422.5:c.-1612dup genomics myocardial infarction[diagnosis] myocardial infarction Yamada Y et al. N Engl J Med. 2002
NM_002422.5:c.-1612dup genomics myocardial infarction[diagnosis] myocardial infarction Beyzade S et al. J Am Coll Cardiol. 2003
NM_002422.5:c.-1612dup genomics acute myocardial infarction[diagnosis] acute myocardial infarction Liu PY et al. Thromb Haemost. 2003
NM_002422.5:c.-1612dup genomics myocardial infarction[diagnosis] myocardial infarction Nojiri T et al. Int J Cardiol. 2003
NM_002422.5:c.-1612dup genomics myocardial infarction[diagnosis] myocardial infarction Zhou X et al. Thromb Haemost. 2004
NM_002422.5:c.-1612dup genomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Liu PY et al. J Thromb Haemost. 2005
NM_002422.5:c.-1612dup genomics acute myocardial infarction[diagnosis] acute myocardial infarction Ghaderian SM et al. Coron Artery Dis. 2010
NM_002422.5:c.-1612dup genomics myocardial infarction[diagnosis] myocardial infarction Sakowicz A et al. Biochem Genet. 2013
NM_002422.5:c.-1612dup genomics acute myocardial infarction[diagnosis] acute myocardial infarction Abd El-Aziz TARH Mohamed Am J Clin Pathol. 2016
NM_002422.5:c.-1612dup genomics death[prognosis (bad)] acute myocardial infarction Abd El-Aziz TARH Mohamed Am J Clin Pathol. 2016
NM_002422.5:c.-1612dup genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Zaliaduonyte-Peksiene D et al. J Renin Angiotensin Aldosterone Syst. 2017
NM_002422.5:c.-1612dup genomics acute myocardial infarction[diagnosis] acute myocardial infarction Du J et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019
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